Auburn won the toss and deferred. South Carolina chose to receive and Auburn defended the south goal.
Kickoff was at 6:48 p.m. CT.
Game attendance was announced as 87,237.
Auburn now leads the all-time series with South Carolina 7-1-1 and is 5-0 against the Gamecocks since South Carolina joined the SEC.
Auburn is now 22-4 in night games at Jordan-Hare Stadium since the 2000 season.
Auburn has now won 28 of its last 32 games played in September and has won eight in a row.
Auburn has now won 58 consecutive games when scoring 30 or more points. The Tigers have not lost when scoring at least 30 points since a 56-49, four-overtime loss to Georgia in 1996.
Auburn is now 4-0 for the second straight season, and the fourth time in the last seven years. Auburn has now started 4-0 in eight of the past 18 years and 29 times in its history.
Auburn finished the night with 334 yards rushing. Entering the game, South Carolina led the SEC in rushing defense, allowing just 59.7 yards per game.
Auburn's rushing totals of 57 carries and 334 yards and the Tigers' total offense number of 492 yards were the most ever for the Tigers against South Carolina. The previous highs were 39 rushes (2005) for 127 yards (2006), and 388 total yards (2005).
Auburn scored first on a 54-yard rush by Cameron Newton on the Tigers' opening possession. It marked the first home game and second game overall that Auburn scored first.
Newton's 54-yard touchdown rush was Auburn's seventh touchdown of at least 35 yards this season.
Auburn's second touchdown drive took 12 plays and consumed 5:30, which was the Tigers' longest scoring drive of the season. The previous long was a nine-play drive that took 4:07 vs. Arkansas State.
Auburn trailed 20-14 at halftime, marking the second straight game that Auburn trailed at halftime.
Auburn forced four turnovers in the second half after only forcing two all season coming into the game.
OT Lee Ziemba extended his consecutive starts streak to 41 games, which is eight shy of the school record held by Will Herring.
Cameron Newton had his second 100-yard rushing game of the season, finishing with 25 carries for 176 yards and three rushing touchdowns, all career highs for the quarterback.
Newton became just the second quarterback in Auburn history with more than one 100-yard rushing game during a career, joining Phil Gargis, who had four from 1974-76.
Newton also threw for two scores, becoming the first player in Auburn history to throw at least two TD passes in each of the first four games of a season.
It marked the second time this season that Newton accounted for five TDs. He had three passing TDs and two rushing TDs against Arkansas State in the season opener.
Newton posted the most rushing yards ever by an Auburn Tiger against South Carolina, surpassing Kenny Irons' total of 117 yards in 2006.
Newton had rushing TDs of 54, 3 and 4 yards, becoming the first Auburn player to rush for three touchdowns in a game since Kodi Burns had three rushing TDs last season against Mississippi State. He has five rushing TDs this season.
Newton's 54-yard touchdown rush on Auburn's first drive was his second longest rush of the season. He had a 71-yard TD run against Arkansas State.
True freshman RB Michael Dyer had his first career 100-yard rushing game, collecting 100 yards on 23 carries.
It marked the first time Auburn had two players go over 100 yards rushing in the same game since Ben Tate and Onterio McCalebb both when over 100 yards last season against Mississippi State.
Wes Byrum finished the night scoring five points, and now needs 44 more points to become Auburn's all-time leading scorer. He passed Damon Duval to move into fourth place in school history with 269 career points.
WR Darvin Adams moved up to 15th on Auburn's career receiving yards list after grabbing four passes for 45 yards. Adams now has 1,274 career receiving yards.
Demond Washington had 76 kickoff return yards on three returns, passing Roderick Hood and Devin Aromashodu for eighth place in Auburn history with 886 career kickoff return yards.
TE Philip Lutzenkirchen had a career-high three catches for 22 yards, and scored his second career touchdown on a 7-yard TD pass from Newton with 13:35 left.
Cameron Newton's 54-yard touchdown rush on Auburn's first drive was his third rushing touchdown of the season, and his second longest. He had a 71-yard TD run against Arkansas State.
Freshman DE Corey Lemonier recorded his first career sack early in the second quarterback.
CB Demond Washington had his first sack of the season and second of his career early in the third quarter.
DB T'Sharvan Bell collected his first career fumble recovery early in the fourth quarter. The fumble was forced by LB Daren Bates, for his first career forced fumble.
Later in the fourth quarter, Mike Blanc recovered his first career fumble, and Josh Bynes was credited with the forced fumble - the second of his career.
Emory Blake scored his second career touchdown and second of the season at 6:23 in the fourth quarter on a 12-yard pass from Cameron Newton.
Josh Bynes' interception at 3:19 in the fourth quarter was his first of the season and the fifth in his career.
Demond Washington's interception with :33 left in the fourth quarter was his first inception of his career.